Hydrogen water - water enriched with hydrogen gas. Medical report on the treatment of cancer and other serious diseases with hydrogen.
We present you a medical report published in m. August 2019, which summarizes research on the application of hydrogen gas (H2) in cancer treatment over the last 15 years. We have kept the structure of the report so that you can easily navigate when you open the text in English. Title of the report: 'Hydrogen gas in cancer treatment' Open the link to read the original text. /https://doi.org/10.3389/fonc.2019.00696/ Both in the official document and at the end of our article, you will find the reference clinical studies (the numbers in parentheses) referenced in the report. Note in "Table 1" after the references at the end of the paper how many of the studies were on patients taking hydrogen gas via H2-rich water/hydrogen water.
Gas signaling molecules (GSMs), composed of oxygen, carbon monoxide, nitric oxide, hydrogen sulfide, etc., play a critical role in regulating signal transmission between cells and cellular homeostasis. Interestingly, through various administrations, these molecules also show potential in cancer treatment. Recently, hydrogen gas (formula: H2) has emerged, as a novel HSM that possesses multiple bioactivities including anti-inflammatory, antioxidant and anticancer. A growing body of evidence shows that hydrogen gas alleviates the side effects caused by conventional chemotherapeutics and inhibits cancer cell and xenograft tumor growth, suggesting its widespread powerful application in clinical therapy. In this review, we summarize these studies and discuss the underlying mechanisms of action. The application of hydrogen gas in cancer treatment is still in its infancy, but further research and development of portable H2 therapy devices are encouraged.
Introduction
Gaseous signaling molecules (GSMs) refer to a group of gaseous molecules, such as oxygen (1), nitric oxide (2), carbon monoxide (3), hydrogen sulfide (4), sulfur dioxide (5, 6), ethylene (7 , 8), etc. These gaseous molecules have multiple critical functions in regulating cell biology "in vivo" through signaling (9). More importantly, some GSMs can serve as therapeutic agents in primary cancer as well as in the treatment of patients resistant to multiple drugs when used directly or certain pharmaceutical formulations (9-13). In addition, some of these GCMs can be generated in the body by various bacteria or enzymes, such as nitric oxide, hydrogen sulfide, indicating that they are body-compatible molecules that exhibit less adverse effects compared with conventional chemotherapeutics (9, 14, 15) . Recently, hydrogen gas has been recognized as another important GMM in biology, showing tremendous potential in health care to prevent cell damage of various nature (16-19).
With its molecular formula, hydrogen gas (H2) is the lightest molecule in nature, representing only about 0.5 parts per million (ppm) of the total gas. Naturally occurring, hydrogen gas is a colorless, odorless, tasteless, nontoxic, highly flammable gas that can form explosive mixtures with air in concentrations ranging from 4 to 74%, which can be triggered by a spark, heat, or sunlight. Hydrogen gas can be generated in small amounts by the hydrogenase of the microbiota of the human gastrointestinal tract, as well as from unabsorbed carbohydrates in the intestine by degradation and metabolism (20, 21). H2 is then partially diffused into the bloodstream and eliminated from the body on exhaled breath (20). This indicates its potential to serve, as a biomarker.
As the lightest molecule in nature, hydrogen gas exhibits deep penetration ability as it can diffuse rapidly across cell membranes (22, 23). A study showed that after oral administration of water enriched with hydrogen gas (hydrogen water) and intraperitoneal administration of super-hydrogen-rich saline (HSRS), the hydrogen concentration reached its peak in 5 min; or in 1 min by intraperitoneal administration of saline enriched with hydrogen gas (23). Another "in vivo" study tested the distribution of hydrogen in the brain, liver, kidney, mesenteric adipose tissue, and thigh muscles when 3% hydrogen gas was inhaled (24). The different concentration of hydrogen gas on reaching saturation status of the body by organ was as follows: liver, brain, mesentery, muscle, kidney, indicating different distributions among organs. Apart from the thigh muscle requiring a longer time to saturate, the other organs need 5-10 minutes to reach Cmax (maximum hydrogen concentration). Distinctively, the liver shows the highest Cmax (24). The information will aid and guide future clinical application of hydrogen gas.
As the lightest molecule in nature, hydrogen gas exhibits the ability to penetrate deeply because it can diffuse rapidly across cell membranes (22, 23). A study showed that after oral administration of water enriched with hydrogen gas (hydrogen water) and intraperitoneal administration of super-hydrogen-rich saline (HSRS), the hydrogen concentration reached its peak in 5 min; or in 1 min by intraperitoneal administration of saline enriched with hydrogen gas (23). Another "in vivo" study tested the distribution of hydrogen in the brain, liver, kidney, mesenteric adipose tissue, and thigh muscles when 3% hydrogen gas was inhaled (24). The different concentration of hydrogen gas on reaching saturation status of the body by organ was as follows: liver, brain, mesentery, muscle, kidney, indicating different distributions among organs. Apart from the thigh muscle requiring a longer time to saturate, the other organs need 5-10 minutes to reach Cmax (maximum hydrogen concentration). Distinctively, the liver shows the highest Cmax (24). The information will aid and guide future clinical application of hydrogen gas.
Although hydrogen gas was investigated as a therapy in a mouse model of flat skin cancer in 1975 (25), its potential in medical application was not significantly explored until 2007, when Oshawa et al. reported that hydrogen could ameliorate cerebral ischemia-reperfusion injury by selectively reducing cytotoxic free radicals (ROS), including hydroxyl radical (- OH) and peroxynitrite (ONOO-) (26). This has caused a worldwide sensation. Under various administrative prescriptions, hydrogen gas has been used as a therapeutic agent for various diseases, such as Parkinson's disease (27, 28), rheumatoid arthritis (29), brain injury (30), ischemic reperfusion (31, 32), diabetes (33, 34), etc.
The most valuable action of hydrogen is that it improves clinical endpoints and surrogate markers, from metabolic diseases to chronic systemic inflammatory disorders and cancer (17). A clinical study in 2016 showed that hydrogen gas intake is safe in patients with post-heart attack syndrome (35), its further therapeutic application in other diseases is becoming increasingly popular.
In this review, we focus on its application in cancer treatment. Most commonly, hydrogen gas exerts its biofunctions by regulating oxidative stress, inflammation, and apoptosis.
Hydrogen gas selectively eliminates the hydroxyl radical and peroxynitrite, and regulates some antioxidant enzymes
So far, many studies have shown that hydrogen gas does not target specific proteins but regulates several key players in cancer, including dangerous free radicals (ROS) and some antioxidant enzymes (36).
ROS are unstable molecules that contain oxygen, including singlet oxygen (O2 -), hydrogen peroxide (H2O2), hydroxyl radical (- OH), superoxide (∙ O - 2), nitric oxide (NO -), and peroxynitrite (ONOO-), among others (37, 38). Once generated "in vivo", due to their high reactivity, ROS can attack proteins, DNA/RNA and lipids in cells, causing distinct damage that can lead to apoptosis. The presence of ROS can cause cellular stress and damage, which can lead to cell death, through a mechanism known as oxidative stress (39, 40). Normally, in a physical state, cells, including cancer cells, maintain a balance between ROS generation and elimination, which is essential for their survival (41, 42). Excessively produced ROS, resulting from a regulatory system imbalance or external chemical attack (including chemotherapy/radiation), can cascade to intrinsic apoptosis, causing highly toxic effects (43-45).
Hydrogen gas acts, as a ROS modulator. First, as shown in the study by Ohsawa et al. hydrogen gas can selectively scavenge the most cytotoxic ROS, - OH, as tested in an acute model of cerebral ischemia and reperfusion (26). Another study also confirmed that hydrogen gas can reduce oxygen toxicity resulting from hyperbaric oxygenation by effectively reducing - OH (46).
Second, hydrogen can induce the expression of some antioxidant enzymes that can eliminate ROS, and it plays a key role in regulating redox homeostasis of cancer cells (42, 47). Studies have shown that upon treatment with hydrogen gas, the expression of superoxide dismutase (SOD) (48), heme oxygenase-1 (HO-1) (49), and nuclear factor erythroid 2-related factor 2 (Nrf2) (50 ) is significantly increased, enhancing its ROS scavenging potential.
By upregulating ROS, hydrogen gas can act as an adjuvant regimen to reduce the adverse effects of cancer treatment, while at the same time not overriding the cytotoxicity of other therapy, such as radiotherapy and chemotherapy (48, 51). Interestingly, due to the overproduction of ROS in cancer cells (38), the administration of hydrogen gas lowers the level of ROS initially, but this provokes a compensatory effect and increased ROS production in cancer cells, leading to their death.
Hydrogen gas suppresses inflammatory cytokines
Inflammatory cytokines are a series of signaling molecules that mediate the innate immune response, dys-regulation of which can contribute to the onset and development of many diseases, including cancer (53-55). Typical inflammatory cytokines include interleukins (ILs) secreted by white blood cells, tumor necrosis factors (TNFs) secreted by macrophages, both of which have shown a close association with cancer initiation and progression (56-59), and both ILs and TNFs can be suppressed by hydrogen gas intake (60, 61).
Chemotherapy-induced inflammation in cancer patients not only causes serious adverse effects (62, 63) but also leads to cancer metastasis and treatment failure (64, 65). By regulating inflammation, hydrogen gas can prevent tumor formation, progression, and reduce the side effects caused by chemotherapy/radiotherapy (66).
Hydrogen gas inhibits/induces apoptosis
Apoptosis, also called programmed cell death, can be induced by external or internal signals and executed by various molecular pathways that serve as one effective strategy for cancer treatment (67, 68). In general, apoptosis can be induced by (1) provoking death receptors on the cell surface (such as Fas, TNF receptors, or TNF-related apoptosis-inducing ligand), (2) suppressing the survival signal (such as epidermal growth factor receptor, mitogen-activated protein kinase, or phosphoinositide 3-kinases), and (3) activation of pro-apoptotic B-cell lymphoma-2 (Bcl-2) family proteins or down-regulating anti-apoptotic proteins (such as X-linked) apoptosis inhibitor protein, survivin, and apoptosis inhibitor) (69, 70).
Hydrogen gas regulates intracellular apoptosis by affecting the expression of apoptosis-related enzymes. At a certain concentration, it can serve as a means to inhibit apoptosis by inhibiting pro-apoptotic B-cell lymphoma-2associated X protein (Bax), caspase-3, 8, 12 and enhancing anti-apoptotic B-cell lymphoma-2 (Bcl-2) (71). Hydrogen gas also serves as a means to induce apoptosis via contrast mechanisms (72), suggesting its potential to protect healthy cells from anticancer drugs or to suppress cancer cells.
H2MEDICAL TEAM: The following are the final points of the report, and in order to keep the article more concise we will only translate their titles and conclusion:
Hydrogen Gas Exhibits Potential in Cancer Treatment
Hydrogen Gas Shows Potential in Cancer Treatment
.....
Hydrogen Gas Relieves the Adverse Effects Related to Chemotherapy/Radiotherapy
Hydrogen Gas Relieves Adverse Effects Associated with Chemotherapy/Radiation Therapy
.....
Hydrogen Gas Acts Synergistically With Thermal Therapy
Hydrogen gas acts synergistically with thermal therapy
.....
Hydrogen Gas Suppresses Tumor Formation
Hydrogen gas suppresses tumor formation
.....
Hydrogen Gas Suppresses Tumor Growth
Hydrogen Gas Suppresses Tumor Growth
Discussion / Conclusion
Hydrogen gas is recognized as a medical gas that has the potential to treat cardiovascular disease, inflammatory diseases, neurodegenerative disorders, and cancer (17, 60). By eliminating hydroxyl radicals and peroxynitrites, as well as through its anti-inflammatory effects, hydrogen gas can assist in preventing/mitigating the adverse effects caused by chemotherapy and radiotherapy without compromising their anticancer potential. Hydrogen gas can also work alone or synergistically with other therapy to suppress tumor growth by inducing apoptosis, inhibiting CSCs-linkage, cell cycle-related factors, etc. Look at "Table 1" and "Chart 1" at the end of the article after the references.
The H2MEDICAL team is truly committed to educating our public as well as contributing to a better quality of life for everyone. Our devices are medically certified and feature maximum therapeutic effect as well as the highest safety class. /see the devices/ Note in "Table 1" after the references at the end of the article, how much of the research was on patients taking hydrogen gas via H2-rich water.
Find out which are the Hydrogen Tolerant Diseases in the menu Hydrogen Medicine.
References
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„Изследванията показват, че малкият размер му позволява да проникне навсякъде, дори в клетъчното ядро и митохондриите. Н2 потушава възпаленията и възстановява увреденото ДНК и РНК, регулира всички биохимични процеси в клетката и довежда организма до състояние на хомеостаза. “
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Discover the difference between hydrogen water and alkaline water. Learn how hydrogen water can improve your health and why it is the better choice.
read moreThe benefits of hydrogen water for skin health
Discover the benefits of hydrogen water for skin health. Learn how hydrogen water can brighten your skin and improve your health. Read our article to learn more.
read moreBest Hydrogen Water Bottle in New Zealand
Discover the best hydrogen water bottle in New Zealand for 2025. Learn about the latest features, proven health benefits, and how to choose the right model for your lifestyle.
read moreHydrogen Water Bottles Recommended by Gary Brecka
Discover why hydrogen water bottles recommended by Gary Brecka are making waves in wellness. Learn about their science-backed benefits, latest features, and how H2MEDICAL delivers the purest, most effective hydrogen water for your health.
read moreAre Hydrogen Water Bottles Good for Pregnant Women?
Discover why hydrogen water bottles benefit pregnant women with improved hydration, reduced oxidative stress, and safer placental health. Explore expert insights now.
read moreThe Role of Hydrogen in Reducing Inflammation
Learn about the role of hydrogen in reducing inflammation and how it can improve your health. Learn more about the benefits of hydrogen water and how it can help you fight chronic diseases.
read moreThe impact of hydrogen on aging
Discover how molecular hydrogen can slow down aging and improve your health. Recent studies reveal its surprising benefits.
read moreInhaling hydrogen to improve mood
Discover how inhaling hydrogen can improve your mood and mental state. A natural and innovative approach to combat stress and anxiety.
read moreHydrogen Water Bottles vs Regular Bottles: What’s the Difference?
Discover the key differences between hydrogen water bottles and regular bottles, from health benefits to advanced technology. Find out why hydrogen water is trending in 2025!
read moreHydrogen Water Bottles for Kids: Safe and Healthy Hydration?
Discover if hydrogen water bottles are safe for kids. Explore benefits, safety tips, and how to choose the best device for healthy hydration.
read moreThe benefits of hydrogen inhalation for brain health
Learn about the benefits of hydrogen inhalation for brain health. Improve your well-being with the latest research and the best products.
read moreHydrogen Inhalation Therapy Research
Learn more about the scientific research on hydrogen inhalation therapy and how it can improve your health. Learn more about the benefits and applications of this innovative therapy.
read moreBest Hydrogen Water Bottle in Ireland
Discover the best hydrogen water bottle in Ireland—explore the science, benefits, and features that make hydrogen water a smart choice for wellness and energy. Try our certified devices today!
read moreAre Hydrogen Water Bottles Legit?
Discover the science-backed benefits of hydrogen water bottles and why the H2MEDICAL PRO model stands out as a top choice for enhancing health and wellness.
read moreBest Hydrogen Water Bottle in the United Arab Emirates
Discover the best hydrogen water bottle in the UAE for 2025—powerful antioxidant benefits, advanced safety, and real clinical results. Feel healthier every day!
read moreHydrogen inhalation for mental health
Discover how inhaling hydrogen can improve your mental health and overall well-being thanks to its unique antioxidant and anti-inflammatory properties.
read moreWhat Is a Hydrogen Water Bottle?
Discover what a hydrogen water bottle is, how it works, its science-backed health benefits, and why it’s the latest wellness trend. Learn how hydrogen water can boost your energy, recovery, and overall health.
read moreThe benefits of hydrogen water for good digestion
Discover the benefits of hydrogen water for gastrointestinal health and learn how it can strengthen your body. Read our comprehensive guide to understand the benefits of hydrogen water.
read moreThe future of hydration: Hydrogen water devices.
Discover the future of hydration with hydrogen water devices. Learn more about the benefits and how you can improve your health.
read moreInhaling hydrogen: a ray of hope for kidney health
Molecular hydrogen is emerging as a promising therapy for a variety of medical conditions, including kidney problems. Learn how this innovative approach can improve the health of your kidneys.
read moreImpact of hydrogen on liver health
Molecular hydrogen offers promising benefits for liver health by reducing inflammation and oxidative stress while improving fat metabolism.
read moreBest Hydrogen Water Bottle in the UK
Discover the best hydrogen water bottle in the UK for 2025! Learn about health benefits, top features, and why H2MEDICAL PRO stands out. Try pure hydrogen water today!
read moreThe role of hydrogen in gut health.
Discover how molecular hydrogen can improve digestive health and your overall well-being. Learn more about the benefits of hydrogenated water for your gut microflora.
read moreHow to Use a Hydrogen Water Bottle?
Discover how to use a hydrogen water bottle for maximum health benefits. Learn step-by-step instructions, science-backed benefits, and why H2MEDICAL’s certified devices are trusted by thousands.
read moreBest Hydrogen Water Bottle in the Philippines
Discover the best hydrogen water bottle in the Philippines—learn how hydrogen-rich water boosts your health, see real data, and find the safest, most effective bottles for your wellness journey.
read moreBest Hydrogen Water Bottles for Seniors and Active Aging
Discover the best hydrogen water bottles for seniors that boost energy, reduce inflammation, and support active aging. Explore top models with safety features and proven health benefits.
read moreUsing hydrogen inhalers in the treatment of fibromyalgia
Discover how hydrogen inhalers can relieve the symptoms of fibromyalgia. An innovative approach to improving quality of life.
read moreHydrogen inhalers in the treatment of liver diseases
Discover how hydrogen inhalers can improve liver health. An innovative approach to treating liver diseases.
read moreCan hydrogen inhalers help improve reproductive health?
Find out how hydrogen inhalers can improve fertility. Recent studies show promising effects on reproductive health.
read moreUsing hydrogen inhalers in the treatment of chronic fatigue
Learn how hydrogen inhalers can help relieve chronic fatigue and improve your quality of life. Information and practical advice.
read moreHydrogen inhalers in the treatment of coordination disorders
Learn how hydrogen inhalers can help treat coordination disorders. An innovative approach to improving quality of life.
read moreTop 5 anti-aging products - 2025
Explore the 5 most popular anti-aging products in 2025. Learn about the latest trends and discover how molecular hydrogen and anti-aging serums can rejuvenate your skin.
read moreHow can inhaled hydrogen raise your energy?
Discover how inhaling hydrogen can boost your energy and improve your well-being. Explore the health and sport benefits of hydrogen.
read moreTop 10 products to reduce oxidative stress - 2025
Discover the 10 best products to reduce oxidative stress in 2025. Discover the latest research and innovative products to improve your health.
read moreBest Hydrogen Water Bottle in 2026
Discover the best hydrogen water bottles of 2026, featuring advanced technology and health benefits. Learn how hydrogen water can improve your well-being and find the perfect bottle for your needs.
read moreBest Supplement for Liver Health in 2025
Discover the best supplements for liver health in 2025. Learn about effective liver support options and how they can boost your overall well-being.
read moreBenefits and Technology of Hydrogen Water Bottles
Discover the benefits and technology behind hydrogen water bottles, enhancing hydration and wellness with antioxidant properties.
read moreHydrogen Water For Hair Growth
Discover how hydrogen water can boost hair growth by reducing oxidative stress, improving hydration, and supporting scalp health. Learn more about its benefits and how to incorporate it into your routine.
read moreBest Supplement for Gut Health in 2025
Discover the best supplements for gut health in 2025. Learn how to boost your digestive wellness with the latest research and top picks.
read moreBest Hydrogen Water Bottle in South Africa
Discover the best hydrogen water bottle in South Africa for 2025! Learn how hydrogen-rich water boosts your health, what features matter, and why H2MEDICAL PRO leads for purity, safety, and performance.
read moreBest Supplement for Brain Health in 2025
Discover the best supplements for brain health in 2025. Learn how hydrogen water, nootropics, and other nutrients can boost your cognitive function and overall well-being.
read moreBest Supplement for Skin in 2025
Discover the best supplements for radiant skin in 2025. Learn about the latest trends, ingredients, and benefits that can transform your complexion.
read moreCan You Drink Too Much Hydrogen Water?
Discover safe daily limits, proven health perks like reduced inflammation, and tips for optimal intake in this expert guide to H2 hydration benefits.
read moreBest Hydrogen Water Device In 2026
Discover the best hydrogen water device in 2026 for enhanced hydration and wellness. Explore top options, key features, and benefits to find the perfect fit for your health routine.
read moreBest Portable Hydrogen Water Bottle In 2026
Discover the best portable hydrogen water bottle in 2026 for enhanced hydration and wellness. Explore top options with high hydrogen concentration, portable designs, and key features to...
read moreIs Hydrogen Water Good for the Kidneys?
Discover if hydrogen water supports kidney health by reducing oxidative stress and inflammation, based on recent studies. Explore benefits, science, and options from H2MEDICAL for better wellness.
read moreHow Much Hydrogen Water Should You Drink Per Day?
Discover the ideal daily hydrogen water intake for better health and energy. Learn science-based guidelines, benefits, and tips to make it part of your routine with expert insights from H2Medical.
read moreBest Hydrogen Water Generator Bottle in 2026
Discover the best hydrogen water generator bottle in 2026 with expert picks, detailed comparisons, and key insights to boost your hydration and wellness.
read moreBest Innovations for Health in 2026
Discover the best innovations for health in 2026, from AI diagnostics to hydrogen therapy, shaping a future of better wellness and care.
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